A 73-year-old woman is prescribed co-amoxiclav for cellulitis. She has a documented cholestatic jaundice reaction after co-amoxiclav five years ago,

Question

A 73-year-old woman is prescribed co-amoxiclav for cellulitis. She has a documented cholestatic jaundice reaction after co-amoxiclav five years ago, current bilirubin is normal and eGFR is 61mL/min/1.73m2. What is the most appropriate action?

Accepted Answer

Query the prescription because previous co-amoxiclav-associated jaundice is a contraindication.

Answer

Supply because current bilirubin is normal.

Answer

Supply with milk thistle to protect the liver.

Answer

Replace co-amoxiclav with flucloxacillin without contacting the prescriber.

Answer

Advise taking half the dose to reduce hepatic risk.

Co-amoxiclav previous cholestatic jaundice — GPhC CRA MCQ

A 73-year-old woman is prescribed co-amoxiclav for cellulitis. She has a documented cholestatic jaundice reaction after co-amoxiclav five years ago, current bilirubin is normal and eGFR is 61mL/min/1.73m2. What is the most appropriate action?