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Pregabalin and zopiclone falls risk — GPhC CRA MCQ

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HardCNS TherapeuticsPregabalin and zopiclone falls riskGPhC CRA

A 61-year-old woman takes pregabalin 150mg twice daily and zopiclone 7.5mg at night. She reports daytime drowsiness and had a fall after drinking wine. Her eGFR is 48mL/min/1.73m2. What is the most important interaction to flag?

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Reveal the answer and explanation

Correct answer: E — Refer for medication review because CNS depression and renal impairment increase harm.

Pregabalin and zopiclone can both cause sedation and impaired coordination, and alcohol adds to CNS depression. Pregabalin also requires caution and dose consideration in renal impairment. A medication review is needed to reduce falls risk and optimise therapy.

Reference: BNF