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Clozapine neutropenia monitoring — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetyClozapine neutropenia monitoringGPhC CRA

A patient prescribed clozapine presents with fever, sore throat and mouth ulcers. He says his latest blood test appointment was missed because he felt unwell. The pharmacy has a valid repeat prescription. What monitoring is required?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Urgent full blood count assessment before further clozapine supply is considered.

Clozapine is associated with neutropenia and agranulocytosis and is subject to mandatory blood monitoring. Fever, sore throat and mouth ulcers are warning symptoms requiring urgent blood count assessment and specialist advice. Pharmacists should not switch antipsychotics independently.

Reference: BNF; Clozapine monitoring service guidance