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Haloperidol in Parkinson's disease — GPhC CRA MCQ

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HardCNS TherapeuticsHaloperidol in Parkinson's diseaseGPhC CRA

A 80-year-old man with dementia becomes acutely agitated after a UTI. A prescription for haloperidol is requested, but his medication history shows Parkinson's disease treated with co-careldopa and recurrent falls. What is the most important interaction to flag?

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Correct answer: D — Query haloperidol because dopamine blockade can worsen Parkinsonism and falls risk.

Haloperidol and other dopamine antagonists can significantly worsen Parkinson's disease symptoms and increase falls risk. Acute agitation should prompt assessment of causes and safer management options. Co-careldopa should not be stopped to accommodate antipsychotic treatment without specialist advice.

Reference: BNF; NICE CKS