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Montelukast neuropsychiatric effects — GPhC CRA MCQ

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HardRespiratory TherapeuticsMontelukast neuropsychiatric effectsGPhC CRA

A 19-year-old student with asthma started montelukast six weeks ago. His mother reports new nightmares, agitation and low mood. He also uses beclometasone and salbutamol. What is the most appropriate action?

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Correct answer: B — Advise prompt prescriber review because montelukast can cause neuropsychiatric reactions.

Montelukast is associated with neuropsychiatric adverse reactions including sleep disturbance, mood changes and agitation. New mental health symptoms after starting treatment should be escalated to the prescriber. The symptoms should not be dismissed as routine or managed by increasing the dose.

Reference: MHRA Drug Safety Update; BNF