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Terbinafine hepatotoxicity — GPhC CRA MCQ

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HardInfectionsTerbinafine hepatotoxicityGPhC CRA

A 46-year-old man is prescribed terbinafine tablets for fungal nail infection. He reports dark urine, pruritus and right upper quadrant discomfort after four weeks. Baseline liver function was normal before treatment. What monitoring is required?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Stop terbinafine and arrange urgent liver function assessment through the prescriber.

Oral terbinafine can cause hepatotoxicity, and symptoms such as dark urine, pruritus and right upper quadrant discomfort require urgent review. Treatment should be stopped pending assessment. Baseline normal liver function does not exclude later drug-induced liver injury.

Reference: BNF; SmPC