A 31-year-old woman taking lamotrigine for epilepsy is prescribed a combined oral contraceptive. She has been seizure-free for two years. The GP asks

Question

A 31-year-old woman taking lamotrigine for epilepsy is prescribed a combined oral contraceptive. She has been seizure-free for two years. The GP asks whether any interaction matters. What is the most important interaction to flag?

Accepted Answer

Combined hormonal contraception can lower lamotrigine concentrations and affect seizure control.

Answer

Combined contraception makes lamotrigine unsuitable for any adult patient.

Answer

Lamotrigine prevents withdrawal bleeding by increasing oestrogen exposure.

Answer

Combined contraception causes acute lamotrigine overdose within hours.

Answer

Lamotrigine markedly reduces the contraceptive effect of oestrogen tablets.

Lamotrigine and combined contraception — GPhC CRA MCQ

A 31-year-old woman taking lamotrigine for epilepsy is prescribed a combined oral contraceptive. She has been seizure-free for two years. The GP asks whether any interaction matters. What is the most important interaction to flag?