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GTN and sildenafil counselling — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsGTN and sildenafil counsellingGPhC CRA

A 62-year-old man asks for advice about chest tightness on exertion. He has been prescribed GTN spray but says he used sildenafil the previous evening. His BP is 118/72mmHg and he is currently pain-free at the counter. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Avoid using GTN after sildenafil and seek urgent help if chest pain occurs.

Nitrates and phosphodiesterase type 5 inhibitors can cause marked hypotension when used together. Because he is currently pain-free, the immediate advice is to avoid GTN within the relevant sildenafil window and seek urgent medical help if chest pain develops. Aspirin is not a substitute for GTN in treating angina symptoms.

Reference: BNF