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Paracetamol duplication in cirrhosis — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentParacetamol duplication in cirrhosisGPhC CRA

A 54-year-old man with decompensated cirrhosis asks to buy co-codamol for back pain. He drinks no alcohol now, has ascites and his recent INR is 1.6. He already takes prescribed paracetamol 1g four times daily. What is the most appropriate action?

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Correct answer: EDo not supply co-codamol and refer for analgesia review because he is already at maximum paracetamol exposure.

Co-codamol contains paracetamol, and adding it to regular paracetamol risks excessive total daily dosing. Decompensated cirrhosis also makes analgesic choice higher risk, particularly with NSAIDs and bleeding/renal concerns. The patient needs prescriber review for a safe pain plan.

Reference: BNF; NICE CKS