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Sulfonylurea hypoglycaemia — GPhC CRA MCQ

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HardEndocrine TherapeuticsSulfonylurea hypoglycaemiaGPhC CRA

An 82-year-old man taking gliclazide 80mg twice daily has eGFR 34mL/min/1.73m2 and reports sweating, tremor and confusion before lunch on several days. He has recently reduced meal sizes after bereavement. What is the most appropriate action?

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Correct answer: D — Arrange review for recurrent sulfonylurea hypoglycaemia

Gliclazide can cause hypoglycaemia, especially in older adults, renal impairment and reduced food intake. The symptoms described are consistent with recurrent hypoglycaemia and require prescriber review of dose and regimen. Glucose tablets may be useful for immediate treatment but do not resolve the cause. Bedtime dosing or dose escalation would increase risk.

Reference: https://www.pharmacyregulation.org/students-and-trainees/pharmacist-education-and-training/registration-assessment