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Finasteride mood adverse effects — GPhC CRA MCQ

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HardAdverse Drug Reactions and SafetyFinasteride mood adverse effectsGPhC CRA

A 45-year-old man taking finasteride 1mg for hair loss says his partner noticed worsening low mood and he has had thoughts that life is not worth living. He asks whether he should buy St John's wort. What is the most appropriate action?

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Correct answer: E — Refer urgently for mental health assessment and discuss finasteride adverse effect reporting

Finasteride has safety warnings about psychiatric adverse effects, including depression and suicidal thoughts. Suicidal ideation requires urgent assessment and safety-netting. St John's wort can interact with many medicines and is not appropriate as a simple OTC solution here. The suspected adverse reaction should be documented and reported where appropriate.

Reference: MHRA Drug Safety Update; BNF