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Terbinafine hepatic impairment — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentTerbinafine hepatic impairmentGPhC CRA

A patient with chronic hepatitis, ALT persistently three times the upper limit of normal and high alcohol intake receives oral terbinafine for onychomycosis. What should happen?

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Correct answer: BDo not supply until the prescriber reviews active liver-disease risk

Oral terbinafine can cause serious hepatotoxicity and is contraindicated or unsuitable in chronic or active liver disease. Existing biochemical abnormality and alcohol exposure require prescriber review before supply; another diagnosis or treatment strategy may be needed.

Reference: BNF: terbinafine: https://bnf.nice.org.uk/drugs/terbinafine/