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Rifampicin and contraception — GPhC CRA MCQ

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HardInfectionsRifampicin and contraceptionGPhC CRA

A 30-year-old woman using a combined oral contraceptive is prescribed rifampicin for suspected latent tuberculosis. She asks whether she needs extra contraception. What would you advise the patient?

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Correct answer: CUse a non-hormonal or specialist-recommended contraceptive strategy during and after rifampicin

Rifampicin is a potent enzyme inducer and can reduce exposure to hormonal contraceptives, risking contraceptive failure. The patient needs clear advice on reliable alternatives, such as non-hormonal methods, and duration after stopping should follow current contraception guidance. Doubling pills is not a safe or reliable solution. Rifampicin adherence is important for infection management.

Reference: BNF; Faculty of Sexual & Reproductive Healthcare guidance