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H. pylori and penicillin allergy — GPhC CRA MCQ

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HardGI TherapeuticsH. pylori and penicillin allergyGPhC CRA

A 36-year-old woman has a prescription for H. pylori eradication: amoxicillin, clarithromycin and lansoprazole. Her allergy record states immediate wheeze and urticaria after amoxicillin as a child. What is the most appropriate alternative?

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Correct answer: D — Query the regimen and request a non-penicillin eradication option

Immediate wheeze and urticaria suggest a potentially IgE-mediated penicillin allergy. Amoxicillin should not be supplied without prescriber review and a suitable alternative eradication regimen should be selected. Omitting a component would create ineffective treatment and resistance risk. Substitution with another penicillin is inappropriate.

Reference: NICE CKS Dyspepsia; BNF