Methotrexate weekly dosing — GPhC CRA MCQ
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Correct answer: D — Clarify and label methotrexate with explicit once-weekly dosing before supply
Methotrexate dosing errors can be fatal, and weekly dosing must be made explicit. Ambiguous directions should be clarified with the prescriber and the dispensing label should clearly state the weekly dose and day where possible. Folic acid is commonly used to reduce adverse effects according to the prescribed regimen. The patient's misunderstanding is a major safety signal.
Reference: BNF; NPSA/MHRA methotrexate safety advice