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Antiemetic in Parkinson's disease — GPhC CRA MCQ

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HardGI TherapeuticsAntiemetic in Parkinson's diseaseGPhC CRA

A 78-year-old woman is prescribed metoclopramide 10mg three times daily for nausea after a viral illness. She has Parkinson's disease and takes co-beneldopa five times daily. What is the most appropriate alternative?

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Correct answer: BAsk the prescriber to choose an antiemetic suitable for Parkinson's disease

Metoclopramide is a dopamine antagonist and can worsen Parkinsonism or antagonise dopaminergic therapy. Prochlorperazine has similar dopamine-blocking concerns. Antiemetic choice in Parkinson's disease requires care and prescriber review, often with specialist input depending on setting. The pharmacist should query the prescription before supply.

Reference: BNF; NICE CKS Parkinson's disease