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Levothyroxine formulation switching — GPhC CRA MCQ

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ModerateEndocrine TherapeuticsLevothyroxine formulation switchingGPhC CRA

A 55-year-old woman with hypothyroidism asks why her levothyroxine brand has changed this month. She reports feeling well but previously had palpitations when a different formulation was used. What is the most appropriate action?

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Correct answer: C — Discuss consistency of levothyroxine preparation and advise reporting recurrent symptoms

Some patients report symptoms after switching levothyroxine preparations, and consistent use of a tolerated product can be considered. The patient should be advised to report symptoms such as palpitations, fatigue or mood change and thyroid function may need checking. Alternating brands or stopping treatment without review is inappropriate. Calcium can reduce levothyroxine absorption.

Reference: BNF; MHRA Drug Safety Update