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Antiepileptic brand continuity — GPhC CRA MCQ

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HardDispensing and SupplyAntiepileptic brand continuityGPhC CRA

A patient collects carbamazepine modified-release tablets and notices the manufacturer is different. She has epilepsy and has been seizure-free for three years on the previous brand. What is the most appropriate action?

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Correct answer: D — Consider maintaining the same manufacturer and discuss any unavoidable change with the prescriber

Some antiepileptic medicines require continuity of supply by brand or manufacturer because changes may affect seizure control or tolerability. Carbamazepine is a medicine where consistency is commonly important. The pharmacist should try to maintain the same product or involve the prescriber if a change is unavoidable. Modified-release tablets should not be crushed unless the product specifically permits it.

Reference: BNF; MHRA antiepileptic drug advice