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Amlodipine ankle oedema — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsAmlodipine ankle oedemaGPhC CRA

A 63-year-old woman started amlodipine 10mg daily 4 weeks ago. She reports new bilateral ankle swelling by evening, no breathlessness, no chest pain and stable weight. Her blood pressure is now 126/74mmHg and eGFR is normal. What is the most appropriate action?

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Correct answer: E — discuss likely amlodipine-related oedema and refer to the prescriber for dose or treatment review

Peripheral oedema is a recognised dose-related adverse effect of amlodipine. The absence of breathlessness, weight gain and renal impairment makes heart failure less likely, but clinical judgement is still needed. The prescriber may reduce the dose or change treatment. OTC diuretics are not appropriate and NSAIDs may worsen fluid retention and blood pressure control.

Reference: BNF; NICE CKS: Hypertension