skip to main content

Co-trimoxazole hyperkalaemia — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardDrug InteractionsCo-trimoxazole hyperkalaemiaGPhC CRA

A renal-transplant recipient taking tacrolimus is prescribed clarithromycin. What is the most important pharmacy action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Urgently review the antibiotic and arrange tacrolimus monitoring

Clarithromycin inhibits CYP3A4 and can sharply increase tacrolimus exposure, causing nephrotoxicity, neurotoxicity and electrolyte disturbance. An alternative antimicrobial is usually preferred; if unavoidable, specialist dose adjustment and close concentrations and renal monitoring are required.

Reference: https://www.pharmacyregulation.org/students-and-trainees/pharmacist-education-and-training/registration-assessment