skip to main content

Gabapentin renal impairment — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardCNS TherapeuticsGabapentin renal impairmentGPhC CRA

A 79-year-old woman is prescribed gabapentin 300mg three times daily for neuropathic pain. Her eGFR is 28mL/min/1.73m2 and she has had two recent falls. She also takes zopiclone at night. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: Equery the dose and sedation risk with the prescriber before supply

Gabapentin is renally cleared and dose reduction is needed in renal impairment. Older age, falls and concurrent zopiclone increase the risk of sedation, dizziness and harm. The pharmacist should query the starting dose and overall risk before supply. Adding other sedating medicines would increase falls risk.

Reference: BNF; NICE CKS: Neuropathic pain