skip to main content

ACE inhibitor angioedema — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardAdverse Drug Reactions and Drug SafetyACE inhibitor angioedemaGPhC CRA

A 60-year-old man started ramipril 5mg daily 2 weeks ago. He arrives with swelling of his lips and tongue but no rash. He is struggling to speak clearly and his blood pressure is 146/84mmHg. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — call 999 for suspected ACE inhibitor angioedema and stop ramipril pending medical review

Lip and tongue swelling after starting an ACE inhibitor suggests angioedema, which can threaten the airway. Emergency assessment is required, and the ACE inhibitor should be stopped pending medical review. Rechallenge with another ACE inhibitor is inappropriate after suspected ACE inhibitor angioedema. Antihistamine alone is not a safe response to airway-related swelling.

Reference: BNF; NICE CKS: Angio-oedema