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Domperidone cardiac risk — GPhC CRA MCQ

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HardGI TherapeuticsDomperidone cardiac riskGPhC CRA

A 76-year-old woman asks to buy a medicine for nausea. She takes amiodarone, furosemide and sertraline, and her recent potassium was 3.3mmol/L. She says a friend recommended domperidone. What is the most appropriate alternative?

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Correct answer: D — avoid domperidone and refer for clinical assessment because of QT-risk factors

Domperidone is associated with QT prolongation and serious cardiac arrhythmias. This patient has several risk factors, including amiodarone use, hypokalaemia and older age. The pharmacist should avoid supply and refer for assessment of nausea and electrolyte status. Grapefruit juice and higher diuretic doses may increase risk rather than reduce it.

Reference: BNF; MHRA drug safety update