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Opioid toxicity — GPhC CRA MCQ

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HardCNS TherapeuticsOpioid toxicityGPhC CRA

A patient's partner asks for advice after finding him very drowsy with slow breathing after taking extra morphine oral solution for severe pain. He also used diazepam bought abroad. His respiratory rate is 7 breaths/min and he cannot stay awake. What is the most appropriate action?

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Correct answer: B — call 999 immediately and give naloxone if available

Marked drowsiness with respiratory depression after opioid and benzodiazepine exposure is a medical emergency. Emergency services should be called and naloxone administered if available, with continued observation because repeat dosing may be needed. Caffeine and waiting are unsafe. Further benzodiazepine would worsen respiratory depression.

Reference: BNF; NICE CKS: Palliative care