skip to main content

Apixaban dose adjustment — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardRenal and Hepatic ImpairmentApixaban dose adjustmentGPhC CRA

An 82-year-old woman with non-valvular AF is prescribed apixaban. She weighs 58kg and her serum creatinine is 145micromol/L. Her eGFR is 34mL/min/1.73m2 and she takes bisoprolol. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — contact the prescriber because a reduced apixaban dose is likely indicated

Apixaban dose reduction is required in NVAF when at least two dose-reduction criteria are met: advanced age, low body weight and raised serum creatinine. This patient meets all three criteria. The pharmacist should query the dose before supply if the prescription does not reflect this. Aspirin is not an appropriate substitute for stroke prevention in AF.

Reference: BNF