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Methotrexate labelling — GPhC CRA MCQ

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ModerateDispensing and SupplyMethotrexate labellingGPhC CRA

A prescription for methotrexate 2.5mg tablets states 'take 6 tablets weekly' but the day of the week is not specified. The patient also has folic acid 5mg once weekly on a different prescription. The dispensing technician asks whether the methotrexate label is acceptable. What is the legal classification/requirement?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — clarify and include the agreed weekly dosing day on the label

Methotrexate dosing errors can be fatal and weekly administration must be made explicit. The pharmacist should clarify the agreed dosing day and label the medicine to support safe use. Supplying 'as directed' is unsafe for a high-risk weekly medicine. Switching tablet strength can increase confusion and should not be done without a clear clinical reason and counselling.

Reference: BNF; MEP; MHRA safety advice