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Statin-associated rhabdomyolysis — GPhC CRA MCQ

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HardAdverse Drug Reactions and SafetyStatin-associated rhabdomyolysisGPhC CRA

A 58-year-old woman on atorvastatin 80 mg reports severe thigh pain and weakness one week after starting fusidic acid tablets for cellulitis. Urine is dark and CK is 12,000 IU/L. What is the most important interaction to flag?

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Correct answer: B — Stop statin exposure and arrange urgent medical assessment for rhabdomyolysis

Severe muscle symptoms with very high CK and dark urine suggest rhabdomyolysis. Fusidic acid has a serious interaction with statins, and urgent medical assessment is required. Renal injury can occur and should be assessed promptly. Dose reduction alone is inadequate in this presentation.

Reference: BNF; MHRA Drug Safety Update