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Opioid toxicity — GPhC CRA MCQ

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HardCNS TherapeuticsOpioid toxicityGPhC CRA

A 81-year-old woman is prescribed oxycodone immediate-release 5 mg four times daily after a fall. She also takes diazepam 5 mg at night and has eGFR 32 mL/min/1.73 m². Her daughter reports new confusion and slow breathing. What is the most appropriate action?

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Correct answer: B — Arrange urgent medical assessment for possible opioid toxicity and CNS depression

Opioids and benzodiazepines have additive CNS and respiratory depressant effects. Renal impairment and older age increase vulnerability to adverse effects. New confusion and slow breathing are red flags for toxicity requiring urgent assessment. Adding sedatives or reassuring without review would be unsafe.

Reference: https://www.pharmacyregulation.org/students-and-trainees/pharmacist-education-and-training/registration-assessment