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Mesalazine renal monitoring — GPhC CRA MCQ

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ModerateGI TherapeuticsMesalazine renal monitoringGPhC CRA

A 60-year-old man with ulcerative colitis starts mesalazine modified-release tablets. He has hypertension treated with ramipril and baseline eGFR 58 mL/min/1.73 m². What monitoring is required?

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Correct answer: D — Renal function should be checked at baseline and periodically during mesalazine treatment

Mesalazine can rarely cause nephrotoxicity, so renal function monitoring is required. Baseline eGFR is already reduced and ramipril adds relevance to renal monitoring. INR, glucose, peak flow and lithium checks are not routine requirements for mesalazine. The pharmacist should confirm monitoring arrangements and counsel about reporting unexplained bruising, fever or worsening symptoms.

Reference: BNF; NICE CKS