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SSRI and NSAID bleeding risk — GPhC CRA MCQ

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ModerateDrug InteractionsSSRI and NSAID bleeding riskGPhC CRA

A 46-year-old woman taking sertraline 100 mg daily asks for naproxen for menstrual pain. She has a history of gastritis and takes no gastroprotection. What is the most important interaction to flag?

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Correct answer: D — Sertraline with naproxen increases gastrointestinal bleeding risk

SSRIs can impair platelet aggregation and NSAIDs increase gastrointestinal mucosal injury. The combination increases bleeding risk, especially with previous gastritis. The pharmacist should consider safer analgesia, need for gastroprotection and prescriber advice if NSAID use is unavoidable. This is a practical OTC interaction to identify before sale.

Reference: BNF