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H. pylori eradication interactions — GPhC CRA MCQ

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HardGI TherapeuticsH. pylori eradication interactionsGPhC CRA

A 49-year-old man with dyspepsia has been prescribed omeprazole, amoxicillin and clarithromycin for H. pylori eradication. He takes carbamazepine for epilepsy and simvastatin 40 mg at night. What is the most important interaction to flag?

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Correct answer: E — Contact the prescriber because clarithromycin has significant interaction risks with his current medicines

Clarithromycin can increase simvastatin exposure and may also interact with carbamazepine. The combination creates a clinically important safety issue that needs prescriber review before supply. The pharmacist should not independently redesign the eradication regimen. Timing changes do not remove CYP3A4-mediated interaction risk.

Reference: BNF; NICE CKS