Clopidogrel and omeprazole — GPhC CRA MCQ

Correct answer: C — Omeprazole can reduce clopidogrel activation and an alternative PPI should be considered

Omeprazole and esomeprazole can inhibit CYP2C19 and reduce conversion of clopidogrel to its active metabolite. In a recent ACS patient, this may reduce antiplatelet effectiveness. A less interacting PPI, such as lansoprazole or pantoprazole, is usually preferred when acid suppression is needed. The pharmacist should avoid casual OTC supply without checking suitability.

Reference: BNF