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Isotretinoin safety requirements — GPhC CRA MCQ

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HardAdverse Drug Reactions and SafetyIsotretinoin safety requirementsGPhC CRA

A 19-year-old woman taking isotretinoin asks why the pharmacy keeps checking pregnancy prevention information each month. She reports low mood and has missed her last pregnancy test appointment. What is the most appropriate action?

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Correct answer: C — Do not supply until pregnancy prevention and safety requirements are resolved with the prescriber

Isotretinoin is highly teratogenic and is subject to strict risk minimisation measures, including pregnancy prevention requirements where relevant. Missed monitoring and low mood both require prescriber review before supply. St John's wort may interact with hormonal contraception and is not appropriate casual advice here. Patient access should be balanced with the mandated safety framework.

Reference: BNF; MHRA Drug Safety Update