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GLP-1 agonist pancreatitis — GPhC CRA MCQ

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HardGI TherapeuticsGLP-1 agonist pancreatitisGPhC CRA

A 48-year-old man taking semaglutide for type 2 diabetes reports severe persistent upper abdominal pain radiating to the back with vomiting. He has lost weight and has no diarrhoea. What is the most appropriate action?

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Correct answer: B — Refer urgently for assessment of possible pancreatitis

GLP-1 receptor agonists can be associated with pancreatitis, and severe persistent abdominal pain radiating to the back with vomiting is concerning. The patient needs urgent assessment and the medicine should be reviewed by a clinician. Simple dyspepsia advice is not sufficient. Dose escalation would be unsafe while pancreatitis is possible.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-87