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PPI hypomagnesaemia — GPhC CRA MCQ

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HardAdverse Drug Reactions and SafetyPPI hypomagnesaemiaGPhC CRA

A 69-year-old man has taken omeprazole 20 mg daily for six years. He now has muscle cramps and dizziness. Blood tests show magnesium 0.48 mmol/L and potassium 3.2 mmol/L. What monitoring is required?

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Correct answer: D — Review long-term PPI need and monitor magnesium with correction of electrolyte disturbance

Long-term PPI treatment is associated with hypomagnesaemia, which can also cause secondary hypokalaemia. The clinical picture and blood results require medication review and electrolyte correction. Ongoing need for PPI should be assessed, especially after prolonged use. INR is not the key monitoring test for this presentation.

Reference: BNF