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Gabapentin renal impairment — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentGabapentin renal impairmentGPhC CRA

A 69-year-old man with diabetic neuropathy presents a new prescription for gabapentin 300 mg three times daily. His eGFR is 24 mL/min/1.73 m² and he takes zopiclone at night. What is the most appropriate alternative?

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Correct answer: E — Query the starting dose and sedation risk with the prescriber before supply

Gabapentin is renally cleared and dose adjustment is required in renal impairment. Starting at 300 mg three times daily may be excessive at eGFR 24, and zopiclone increases CNS depression and falls risk. The prescriber should review dose and monitoring. The pharmacist should also counsel about dizziness, somnolence and driving.

Reference: BNF