Valproate reproductive safety — GPhC CRA MCQ
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Correct answer: C — Supply if clinically appropriate but urgently refer to prescriber for specialist review and Pregnancy Prevention Programme discussion
Valproate is highly teratogenic and subject to strict risk minimisation measures. Abrupt discontinuation can cause seizures and should not be advised without specialist input. The pharmacist should ensure the patient receives current warnings and prompt prescriber or specialist review regarding contraception and alternatives. This balances immediate seizure safety with reproductive risk.
Reference: BNF; MHRA Drug Safety Update