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Apixaban dose review — GPhC CRA MCQ

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HardCardiovascular TherapeuticsApixaban dose reviewGPhC CRA

A 83-year-old man with AF is prescribed apixaban 5 mg twice daily. He weighs 58 kg, serum creatinine is 142 micromol/L and he is also taking verapamil. What monitoring is required?

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Correct answer: D — Check renal function, weight and appropriateness of apixaban dose with the prescriber

Apixaban dose reduction in AF depends on age, body weight and serum creatinine criteria, and this patient meets more than one relevant criterion. Renal function and weight should be considered before confirming the dose. INR monitoring is not used for apixaban, but baseline and periodic renal, liver and full blood count monitoring are important. Verapamil also adds interaction considerations through P-gp/CYP pathways.

Reference: BNF