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Exercise-induced bronchoconstriction — SCE Respiratory MCQ

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HardMedical Conditions in SportExercise-induced bronchoconstrictionSCE Respiratory

A 22-year-old with a pathogenic FLCN variant and basal medial lung cysts has no renal lesion on baseline imaging. Which renal-cancer surveillance plan follows ERN GENTURIS guidance?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Lifelong renal MRI with contrast every 1–2 years, starting from age 20

Explanation lettering: B = shown as A · A = shown as B · E = shown as C · C = shown as D · D = shown as E

C is correct. Birt-Hogg-Dubé syndrome confers lifelong renal-cell-carcinoma risk across pathogenic FLCN variants. ERN GENTURIS recommends renal surveillance from age 20, every one to two years, preferably with contrast-enhanced MRI to avoid repeated radiation and improve small-mass detection; ultrasound is an alternative when MRI is unsuitable. Chest CT is not a renal-surveillance substitute, urinary cytology does not detect the characteristic renal tumours reliably, and pulmonary or cutaneous manifestations are not prerequisites for cancer risk.

Reference: https://pmc.ncbi.nlm.nih.gov/articles/PMC11607457/