Linezolid and SSRI — GPhC CRA MCQ
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Correct answer: D — Increased risk of serotonin toxicity
Linezolid has monoamine oxidase inhibitor activity and may precipitate serotonin toxicity with SSRIs. In this vignette, "Increased risk of serotonin toxicity" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.
Reference: BNF