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Warfarin and amiodarone — GPhC CRA MCQ

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ModerateDrug InteractionsWarfarin and amiodaroneGPhC CRA

A patient on warfarin starts amiodarone for atrial fibrillation. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Increased anticoagulant effect and bleeding risk

Amiodarone can increase warfarin effect and INR. In this vignette, "Increased anticoagulant effect and bleeding risk" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF