Clarithromycin and simvastatin — GPhC CRA MCQ

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EasyDrug InteractionsClarithromycin and simvastatinGPhC CRA

A patient on simvastatin receives clarithromycin for pneumonia. What is the most important interaction to flag?

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Correct answer: E — Increased risk of statin toxicity

Clarithromycin inhibits metabolism of simvastatin and raises myopathy risk. In this vignette, "Increased risk of statin toxicity" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF