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Rifampicin and contraception — GPhC CRA MCQ

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ModerateInfectionsRifampicin and contraceptionGPhC CRA

A patient on a combined oral contraceptive is prescribed rifampicin for tuberculosis exposure management. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Reduced contraceptive efficacy

Rifampicin is a strong enzyme inducer and can reduce hormonal contraceptive effectiveness. In this vignette, "Reduced contraceptive efficacy" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; NICE CKS