SSRI and NSAID — GPhC CRA MCQ

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ModerateDrug InteractionsSSRI and NSAIDGPhC CRA

A patient taking sertraline requests ibuprofen for period pain. What is the most important interaction to flag?

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Correct answer: B — Increased risk of gastrointestinal bleeding

SSRIs and NSAIDs together increase bleeding risk, particularly gastrointestinal bleeding. In this vignette, "Increased risk of gastrointestinal bleeding" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF