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Isotretinoin safety — GPhC CRA MCQ

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ModerateAdverse Drug Reactions and SafetyIsotretinoin safetyGPhC CRA

A patient prescribed isotretinoin by dermatology asks why blood tests and pregnancy checks are required. What monitoring is required?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Liver function tests, lipids and pregnancy testing where relevant

Isotretinoin has teratogenicity and metabolic/hepatic safety monitoring requirements. In this vignette, "Liver function tests, lipids and pregnancy testing where relevant" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; MHRA Drug Safety Update