NSAID hypersensitivity — GPhC CRA MCQ

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HardAdverse Drug Reactions and SafetyNSAID hypersensitivityGPhC CRA

A patient developed wheeze and urticaria after ibuprofen and asks for naproxen. What is the most appropriate alternative?

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Correct answer: A — Avoid NSAIDs and seek clinical advice for analgesic choice

NSAID hypersensitivity can cross-react across NSAIDs, so alternatives should be selected carefully. In this vignette, "Avoid NSAIDs and seek clinical advice for analgesic choice" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; MHRA Drug Safety Update