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Apixaban and naproxen — GPhC CRA MCQ

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ModerateDrug InteractionsApixaban and naproxenGPhC CRA

A patient taking apixaban asks to buy naproxen for dental pain. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Increased risk of bleeding

NSAIDs increase bleeding risk when combined with direct oral anticoagulants. In this vignette, "Increased risk of bleeding" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF