Spironolactone in heart failure — GPhC CRA MCQ

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HardCardiovascular TherapeuticsSpironolactone in heart failureGPhC CRA

A patient with heart failure is started on spironolactone 25 mg daily. They also take ramipril and furosemide. What monitoring is required?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Urea, creatinine, eGFR and electrolytes

Spironolactone can cause hyperkalaemia and renal impairment, particularly with ACE inhibitors. In this vignette, "Urea, creatinine, eGFR and electrolytes" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; NICE CKS