Valproate and lamotrigine — GPhC CRA MCQ
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Correct answer: B — Increased lamotrigine toxicity
Valproate inhibits lamotrigine metabolism and increases serious rash risk. In this vignette, "Increased lamotrigine toxicity" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.
Reference: BNF