High-intensity statin intolerance — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsHigh-intensity statin intoleranceGPhC CRA

A patient taking atorvastatin 80 mg has dose-related muscle symptoms with normal creatine kinase. Secondary prevention is still required. What is the most appropriate alternative?

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Correct answer: E — Reduce dose or switch to another statin regimen

Statin intolerance should be managed by adjusting dose or switching rather than abandoning lipid lowering without review. In this vignette, "Reduce dose or switch to another statin regimen" is the safest single best answer. The other options are less appropriate because they miss the key clinical risk, conflict with UK medicines guidance, or delay needed review.

Reference: BNF; NICE CKS